In this project we seek: to define and classify hereditary tumors of the nervous system in addition to the eight such disease already recognized; to add to the clinical description and natural history of these diseases; to suggest methods for early diagnosis; evaluate present modes of treatment; and develop methods for pre-clinical detection and screening. BIBLIOGRAPHIC REFERENCE: Horton, W., Wong, V., Eldridge, R.: Von Hippel-Lindau Disease: Clinical and Pathological Manifestations in Nine Families with 50 Affected Members. Arch. Int. Med. 136(6):769-777, July 1976.